Adding trusted Sites for all users. Not to sound in poor humor, but it seems you misunderstood the question. The HKCU key in either SoftwareMicrosoftWindowsCurrent. VersionInternet SettingsZone. MapDomains or Esc. Eset Endpoint Antivirus Offline Update Programs. Domains Enhanced Security Configuration being preferred appears to successfully. HKLM does not populate to all users, and thus new users on the machine will not have that trusted site. I have successfully recreated this issue while trying to do basically the same thing setting. Running as an admin with UAC disabled on Windows 7 Ultimate w IE8, I can successfully apply the following registry script Windows Registry Editor Version 5. HKEYLOCALMACHINESoftwareMicrosoftWindowsCurrent. VersionInternet SettingsZone. MapEsc. DomainsHKEYLOCALMACHINESoftwareMicrosoftWindowsCurrent. VersionInternet SettingsZone. MapEsc. Domainsmydomain. HKEYLOCALMACHINESoftwareMicrosoftWindowsCurrent. VersionInternet SettingsZone. MapEsc. Domainsmydomain. Hklm Software Wow6432node Wow6432node' title='Hklm Software Wow6432node Wow6432node' />The WorryFree Business Security Standard solution consists of an onpremise server Security Server and desktop protection software Security Agent. I have verified that the keys are in place in HKLM, but upon actually visiting the site https portal. Internet. I have rebooted, no change. The same occurs if I add the domain to Domains, instead of Esc. Domains. Currently. OP is trying to reach what appears to be a PACS viewer, I assume he is wasting a doctors or radiologists time, and they. Basically, the initial question still stands How can we apply this trusted sites list to ALL USERS of the machine with one deployment through the registry and without employing group policy, and not to every user individuallyI already know how to start a program when a user logs onto Windows 7. Not easy to find, but once you know the trick, it is easy as pie Place a shortcut into C.